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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]

Selenium, by incorporating into selenoproteins, is involved in one of the two antioxidant systems: the thiol redox system, including glutathione (GSH), glutaredoxin, GSH reductase, and GSH-Px and the thioredoxin (Trx) system, which consists of thioredoxin (Trx), Trx peroxidase and TrxR [76]

For the final AuNR@GO-porphyrin nanocomposites, HRTEM characterization revealed a well-defined core-shell structure, consisting of 1015 nm AuNRs embedded in 12 nm GO layers

Acknowledgements The authors acknowledge the Australian Medical Research Future Fund (2007488) for funding